The pharmaceutical industry uses routine drug dissolution testing to provide critical in vitro drug release information for quality control purposes and to optimise the amount of drug available to the body. These tests are done 'in-vitro' and are now rigorously and comprehensively defined in the respective Pharmacopoeia.
For the test, dissolution vessels which are put into a water bath are used. All vessels should not only meet the physical dimensions but have a hemispherical bottom which means that they should be perfectly rounded with no obvious join with the sides and no 'bumps' of glass on the inside. Wall thicknesses should be even and reproducible.
Dissolution Tests are rigorously and comprehensively defined in the respective Pharmacopoeia
The reproducibility of the dissolution is important
The reproducibility depends much on the tolerances of the vessels used