White Papers and Technical Documents:
HALO® PCS: New Column Chemistry Options for Basic Compounds

In LC and LCMS separations, tailed peak shapes with basic compounds at high concentrations is a problem commonly observed when low ionic strength mobile phases, such as those using formic acid are employed. A way to improve the peak shape and sample load capacity is to use a stationary phase containing a positive charge.  The new HALO^® PCS line of columns are positively charged surface chemistries which maintain peak symmetry at higher loading capacities and provide alternate selectivities from other  C18 and Phenyl-Hexyl bonded phases.

Built upon proven Fused-Core^® technology  and available in both a 90 Å and 160 Å pore size for small molecule and peptide analysis, the columns are optimized to deliver performance for reproducible, high efficiency LC and LCMS separations.

 

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HALO^® PCS: New Column Chemistry Options for Basic Compounds

Reversed Phase Positive Charge Surface Phenyl-Hexyl Phase for Improved Separations of Basic Analytes

 

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Improved Bioseparations with HALO^® PCS C18 PEPTIDE

What to Expect from HALO^® PCS C18