HALO® Elevate C18

For laboratories with many alkaline applications

The organo-silane modified surface of the HALO^® Elevate C18 phase has a wide application range of pH 2-12. Thanks to the high pH stability, bases can be analysed uncharged. This avoids secondary interactions, resulting in high peak symmetries. The modification prevents degradation of the silica material when used at high pH and high temperature.

The HALO^® Elevate C18 is based on fused-core technology for fast efficient separation.

• Organo-Silane modified surface for alkaline resistance
• very stable at high pH values
• improved peak shape and loading for basic analytes
• wide application range from pH 2-12 for robust method development

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HALO^® Elevate C18

Applications

High Temperature/ pH Amitriptyline Stability using HALO^® Elevate

Impact of pH on Retention for HALO^® Elevate

Elevating pH to Improve a Drugs of Abuse Separation

Nicotine Analysis Using HALO^® Elevate C18

Separation of Antidepressants on HALO^® Elevate

Omeprazole Analysis Using HALO^® Elevate C18

The organo-silane-modified surface makes these columns very stable at high pH values.

When analysing amitriptyline at a pH value of 10, it was found that the retention only shifted by 1 % after 500 injections (or 20,000 column volumes).

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